Signed by the Orioles for a reported $100,000 bonus in 1958, Nicholson hit with power wherever he went, but became the easiest batter in major league history to strike out, fanning once every 2.48 at-bats. He led the Northern League with 35 HR in 1959 and was rushed to Baltimore, where he struck out 55 times in just 113 trips in 1960. Unsuccessful again in 1962, he was sent to the White Sox in a 1963 trade for Luis Aparicio. He hit a team-leading 22 home runs in 1963, but struck out 175 times to set a since-broken ML record. Platooned by the Astros in 1966, Nicholson batted a career-high .246 before being traded to Atlanta and subsequently returning to the minors.