Did Negro League teams ever play against Major League teams?

From the 1920s through the 1940s exhibition games between Negro League stars and major league stars were both common and very popular with fans. Typically, such games were played between squads of “all-stars” from both leagues. The most famous series of exhibition games were played in 1946 between a Negro League all-star squad organized by Satchel Paige and a squad of major league all-stars assembled by famed Cleveland Indians pitcher Bob Feller.

Throughout the years, games between Negro League squads and major leaguers were fairly evenly split, demonstrating the relatively equal levels of competition that existed in the separate leagues.