After three mediocre seasons in Philadelphia, Cardwell was traded to the Cubs in mid-1960 and pitched a no-hitter against St. Louis in his first start for his new team, the only pitcher ever to do so. The durable pitcher led the NL with 38 starts for the 1961 Cubs and won a career-high 15 games. He sandwiched two fine seasons in Pittsburgh around severe arm trouble in 1964. His 13-10 mark in 1965 was dragged down by six one-run losses. Cardwell was a valuable swingman for the Mets (1967-70) and helped them to their 1969 World Championship with his experience. After going 3-9 by late July, he won five straight, including a 1-0 game against the Pirates in which he drove in the only run.