Atlanta Braves closer Gene Garber holds the record for most losses by a reliever. In 1979 he went 6-16 for the Bravos, saving 25 games in the process. Because they were fourth-to-last in scoring, the team did not win its share of extra-inning battles, and Garber took some of those losses. He was no stranger to losing his share of relief appearances, however. Though he didn’t start a single game after 1973, he endured four seasons of double-digit losses.