On June 24, 1962, the New York Yankees and the Detroit Tigers played a 22-inning marathon that the Yankees eventually won. Detroit pitcher Phil Regan gave up the game-winning homer to Jack Reed, who would never hit another home run in his career. Jim Bouton got the victory for the Yanks.
In terms of innings played, the game ranks fifth all-time, behind two 23-inning games, three 24-inning games, two 25-inning games, and one 26-inning game. Seven other games have gone 22 innings. At an even seven hours, the game was far shorter than the current record holder, a 25-inning affair on May 9, 1984 between the Chicago White Sox and Milwaukee Brewers. That contest lasted 8 hours and 6 minutes.